GERD is treated with life-style changes, antacids, histamine antagonists (H2 blockers), proton pump inhibitors (PPIs), pro-motility drugs, foam barriers, surgery, and endoscopy. Nausea is uncommon in gastroesophageal reflux. In some patients, however, it may be frequent or severe and may result in vomiting. In fact, in patients with unexplained nausea and/or vomiting, GERD is one of the first conditions to be considered. It is not clear why some patients with GERD develop mainly heartburn and others develop mainly nausea. The type of esophageal cancer associated with Barrett’s esophagus (adenocarcinoma) is increasing in frequency. It is not clear why some patients with GERD develop Barrett’s esophagus, but most do not.
Barrett’s esophagus can be recognized visually at the time of an endoscopy and confirmed by microscopic examination of biopsies of the lining cells. Then, patients with Barrett’s esophagus may require periodic surveillance endoscopies with biopsies.